This study showed that a majority of patients preferred adapalene 0.1% gel over tretinoin 0.025 % cream and that it caused significantly less skin irritation. 32 patients experienced mild to moderately severe adverse events, 3patients had adverse events considered to be drug related (two with skin discomfort one with skin dryness). In a study done by Dunlap FE, Mills OH1, adapalene 0.1% gel showed significantly less irritating to the skin in terms of producing erythema, dryness, desquamation and burning/stinging (P< 0.02). In our study, Side effects were more commonly seen in patients who applied topical tretinoin than in patients who applied topical adapalene. Clinical photographs of the lesions were taken before the commencement of therapy and after the completion of therapy. Side effects were recorded at 4th week and 8th week. Reduction percentage was calculated by calculating the percentage reduction in the average number of lesions from GR-0 to GR-4. Grades were calculated every 4 weeks and recorded respectively at 0, 4, and 8 weeks. Grade 2 has comedones, many papules and few pustules. Grade 1 has only comedones and few papules. First 25 patients who came to study centre, within the study period, having acne, fulfilling inclusion and exclusion criteria, willing to apply topical retinoids irrespective of age, sex, occupation or grade of Acne were given topical adapalene 0.1% and last 25 patients were grouped for topical tretinoin 0.04%.Īccording to the number of acne lesions on the face, patients were graded into grade 1 and grade 2 initially. Patients were randomly selected and grouped to avoid and minimise bias as much as possible. Consent was obtained from the patients prior to enrolment into the study. All the patients attending the Outpatient Department of Dermatology in Meenakshi Medical College and Research Institute, with Acne grade 1 and grade 2 lesions were included in the study. Randomised prospective comparative clinical trial with sample size of 50 patients who are recruited from department of dermatology of Meenakshi Medical College and Research Institute, Kanchipuram, Tamil Nadu, India. Adapalene (synthetic naptholic acid derivative) is a third-generation topical retinoid. 1% strengths in cream, gel and liquid formulation. 7 Tretinoin is a first-generation topical retinoid available in 0.025%, 0. 5, 6 Topical retinoids have the following effects: Reduces the number and formation of precursor lesions, reduces mature comedones, exhibits anti-inflammatory effect and promotes normal desquamation of follicular epithelium. Mechanisms of action of retinoic acid are: Restoration of disturbed keratinisation, increase in cell turnover and decrease in cohesiveness of stratum corneum, and regulation of prostaglandin synthesis. 2 The various retinoid preparations available are tretinoin, isotretinoin, adapalene and tazarotene. Vitamin A plays a role in keratinisation. 1 It is multifactorial, of which Propioniobacterium acne and Sebum play an important role in etiopathogenesis. Hence adapalene is a safe and effective in treatment of acne.Īcne is a chronic, self-limiting inflammatory disease of pilosebaceous unit. Adapalene was better tolerated than tretinoin. Side effects were more commonly seen in patient treated with topical Tretinoin than with topical Adapalene. Whereas in patients who applied tretinoin only few were reduced to grade 0 and many were in grade I and grade II. 00) and pustule (p= 0.001).Ĭonclusion: In Patients who applied adapalene, most of them were reduced to grade 0 and grade I and only few were in grade II. Highest reduction in number of lesions with both topical retinoids was for comedones (p< 0. Thus, Adapalene was found superior to Tretinoin in reducing average number of lesions. 1% produced numerically greater lesion reduction than tretinoin 0. Materials and Methods: Randomized prospective comparative clinical trial with sample size of 50 patients who are recruited from department of dermatology of MMCH&RI. It is multifactorial, of which Propioniobacterium acne and Sebum play an important role in etiopathogenesis.Īims and Objectives: The aim of the study is to compare efficacy of Tretinoin and Adapalene in Acne Vulgaris and to compare the side effects of topical tretinoin and adapalene. Background: Acne is a chronic, self-limiting inflammatory disease of pilosebaceous unit.
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